Human recombinant factor 8 with commercial name(?) “ReFacto AF 500iu"

 Type of Factor VIII

 In general, there are two types of factor VIII, one factor VIII derived from blood plasma, and another type of factor VIII is a recombinant. The difference between the recombinant factor VIII and the plasma-derived factor VIII is that, because it is no longer produced from plasma, there is not a risk of possible contamination of viruses, including the AIDS virus.

 Hemophilia disease

 Haemophilia, is a mostly  inherited genetic disorder that impairs the body's ability to  make blood clots, a process needed to  stop bleeding. This results in people bleeding longer after an injury, surgery, easy  bruising, and an increased risk of bleeding inside joints or the brain. Bleeding into a joint can result in permanent damage while bleeding in the brain can result in long term headaches, seizures, or a decreased level of consciousness. There are two main types of haemophilia:  haemophilia A, which occurs due to not enough clotting factor VIII, and haemophilia B, which occurs due to not enough clotting  factor IX. They are typically inherited from one's parents  to child through an  X chromosome.

 The mechanism of action of factor VIII

 Recombinant activated factor VII (rFVIIa) has proven both safe and efficacious in the treatment of bleeding episodes in patients with hemophilia A.   The coagulation factor is injected into the bloodstream. As soon as a sufficient amount of coagulation factor reaches the affected area, bleeding stops. Also When bleeding is uncertain coagulation factor VIII is needed. If bleeding is likely, a recombinant coagulation factor VIII should be injected.  Patients should never wait until the joint is painful, swollen and hot. There is no definitive treatment for hemophilia, but with coagulation factors, hemophilia can have normal life. Without coagulation factors, people with severe hemophilia experience problems, and they may even have a disability and can not perform normal and routine tasks.



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